MBDSTFA (MTB-TFA or MTBSTFA) is a silylation reagent which donates a tert-butyldimethylsilyl group (TBDMS) for derivatizing active hydrogen atoms in hydroxyl, carboxyl and thiol groups, primary and secondary amines as well as amino acids. Fast reactions (typically 5–20 min) with high yields (> 96 %). By-products are neutral and volatile.TBDMS ethers are more stable than the corresponding TMS ethers. The chromatographic retention times are longer due to the large protecting group, which may improve some separations. Due to the high molecular ion concentration at M+-57 useful for GC-MS applications. These products contain harmful substances which must be specially labeled as hazardous. For detailed information please see SDS.
| Selling unit | 10x1 mL, 20x1 mL |
| Method | Gas chromatography (GC), derivatization |
| Composition | N-methyl-N-tert-butyldimethylsilyl-trifluoroacetamide (MBDSTFA) |
| Derivatization type | Silylation |
| Recommended application(s) | Amines, Derivatization, Derivatizing of active hydrogen atoms in hydroxyl, carboxyl and thiol groups, Primary and secondary amines, Silylation reagent |
| Storage temperature | 2–8 °C / 36–46 °F |
| Hazardous material | Yes |
WARNING
H226 Flammable liquid and vapour.H302 Harmful if swallowed.H315 Causes skin irritation.H319 Causes serious eye irritation.
P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking.P233 Keep container tightly closed.P240 Ground/bond container and receiving equipment.P241 Use explosion-proof [electrical/ventilating/lighting] equipment.P242 Use non-sparking tools.P243 Take precautionary measures against static discharge.P264 Wash hands thoroughly after handling.P264 Wash hands thoroughly after handling.P264W Wash with water thoroughly after handling.P270 Do not eat, drink or smoke when using this product.P280 Wear protective gloves/protective clothing/eye protection/face protection.P280sh Wear protective gloves/eye protection.P280sh Wear protective gloves/eye protection.P301+312 IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.P302+352 IF ON SKIN: Wash with plenty of water.P303+361+353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].P305+351+338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.P330 Rinse mouth.P332+313 If skin irritation occurs: Get medical advice/attention.P337+313 If eye irritation persists: Get medical advice/attention.P362+364 Take off contaminated clothing and wash it before reuse.P370+378 In case of fire: Use suitable extinguisher media to extinguish.P403+235 Store in a well-ventilated place. Keep cool.P501 Dispose of contents/container to regulated waste treatment.P501 Dispose of contents/container to regulated waste treatment.
